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Trypanosomes are characterised by the possession of a single flagellum and a subpellicular microtubule cytoskeleton. The flagellum is more than an organelle for motility; its position and polarity along with the sub-pellicular cytoskeleton enables the morphogenesis of a distinct flagellar pocket and the flagellar basal body is responsible for positioning and segregating the kinetoplast--the mitochondrial genome. Recent work has highlighted the molecules and morphogenesis of these cytoskeletal/flagellum structures and how dynamic events, occurring in the flagellar pocket and kinetoplast, are critical for host-parasite interactions.

Type

Journal article

Journal

Curr Opin Microbiol

Publication Date

08/2003

Volume

6

Pages

365 - 370

Keywords

Animals, Flagella, Host-Parasite Interactions, Humans, Trypanosoma brucei brucei, Trypanosomiasis, African, Virulence