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Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function is proposed. All are transcription units that tether their target promoters close to, or distant from, transcriptional hot spots (or 'factories').

Original publication

DOI

10.1186/1756-8935-5-1

Type

Journal article

Journal

Epigenetics Chromatin

Publication Date

09/01/2012

Volume

5