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Six patients with autoimmune thrombocytopenic purpura (three of whom had CLL/NHL and one previous Hodgkin's disease) refractory to conventional therapy were treated with an antilymphocyte monoclonal antibody directed at CDw52 (CAMPATH-1). We observed response in four of the five evaluable patients; in three patients the response has lasted more than 4-9 months. However, response did not occur in most cases until 4-6 weeks after the commencement of the antibody therapy, suggesting that the mechanism of action is probably that of immune modulation.

Type

Journal article

Journal

Br J Haematol

Publication Date

07/1993

Volume

84

Pages

542 - 544

Keywords

Adult, Antibodies, Monoclonal, Antigens, CD, Antigens, Neoplasm, Female, Glycoproteins, Hodgkin Disease, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin, Male, Middle Aged, Platelet Count, Purpura, Thrombocytopenic, Idiopathic