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Cell-to-cell viral transmission facilitates the propagation of HIV-1 and human T cell leukemia virus type 1. Mechanisms of cell-to-cell transmission by retroviruses were not well understood until the recent description of virological synapses (VSs). VSs function as specialized sites of immune cell-to-cell contact that direct virus infection. Deciphering the molecular mechanisms of VS formation provides a fascinating insight into how pathogens subvert immune cell communication programs and achieve viral spread.

Original publication

DOI

10.1172/JCI22812

Type

Journal article

Journal

J Clin Invest

Publication Date

09/2004

Volume

114

Pages

605 - 610

Keywords

Cell Communication, HIV Infections, HIV-1, HTLV-I Infections, Human T-lymphotropic virus 1, Humans, Immune System, Intercellular Junctions, Virus Replication