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The sequence A-A-U-A-A-A is present in six different purified messenger RNA molecules (specifically the alpha-and beta-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRNA of mouse (MOPC 21) and the ovalbumin mRNA of chicken) about 20 residues away from the 3'-terminal poly (A) sequence. In addition, a large selection of the 3' non-coding regions of rabbit and human globulin mRNAs (both the alpha and beta globin mRNAs) are 85% homologous, demonstrating that this region is significantly conserved in evolution.

Type

Journal article

Journal

Nature

Publication Date

16/09/1976

Volume

263

Pages

211 - 214

Keywords

Animals, Base Sequence, Biological Evolution, Chickens, Globins, Humans, Immunoglobulin Light Chains, Mice, Myeloma Proteins, Ovalbumin, Poly A, RNA, Messenger, Rabbits, Species Specificity