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The budding yeast Cdc14 phosphatase reverses Cdk1 phosphorylation to promote mitotic exit. Although Cdc14 activity is thought to be restricted to anaphase, we found that dephosphorylation of the Dsn1 kinetochore protein in metaphase requires Cdc14. These data suggest that there is a nonnucleolar pool of active Cdc14 prior to anaphase.

Original publication

DOI

10.1534/genetics.110.123653

Type

Journal article

Journal

Genetics

Publication Date

12/2010

Volume

186

Pages

1487 - 1491

Keywords

Anaphase, CDC2 Protein Kinase, Cell Cycle Proteins, Chromosomal Proteins, Non-Histone, Kinetochores, Mitosis, Phosphorylation, Protein Tyrosine Phosphatases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins