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Phosphorylation of the Ndc80 kinetochore protein by the Ipl1/Aurora B kinase reduces its microtubule binding activity in vitro. We found that kinetochore-bound Ndc80 is phosphorylated on Ipl1 sites in vivo, but this phosphorylation is not essential. Instead, we show that additional Ipl1 targets contribute to segregation and the spindle checkpoint.

Original publication

DOI

10.1534/genetics.109.109041

Type

Journal article

Journal

Genetics

Publication Date

12/2009

Volume

183

Pages

1591 - 1595

Keywords

Amino Acid Sequence, Aurora Kinases, Intracellular Signaling Peptides and Proteins, Kinetochores, Microtubules, Mutation, Nuclear Proteins, Phosphorylation, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins