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During S phase, DNA replication begins at numerous sites throughout the genome. Textbooks would have us believe that each replication fork tracks along the immobile DNA until it runs into the adjacent fork, but recent results question this view. Various studies show that replication forks are concentrated in immobile 'factory' units throughout the nucleus. Each factory contains as many as 40 different replication forks and associated polymerases. These findings suggest that newly synthesized DNA is extruded as each template moves like a conveyor through the factory.

Type

Journal article

Journal

Trends Cell Biol

Publication Date

02/1994

Volume

4

Pages

48 - 52