Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The recent discovery that many cancer cells have centrosomal abnormalities suggests a link between centrosomes and cancer. Members of the transforming acidic coiled-coil (TACC) family of proteins have been implicated in cancer and are concentrated at centrosomes, where they regulate microtubule stability. I discuss a model of how the TACC proteins might contribute to cancer. This model predicts that defects in TACC function can make important contributions to the development of cancer but are unlikely to be the primary cause of cancer. The model might also apply to several other centrosomal proteins that have been linked to cancer.

Type

Journal article

Journal

Trends Cell Biol

Publication Date

05/2002

Volume

12

Pages

222 - 225

Keywords

Animals, Centrosome, Drosophila, Drosophila Proteins, Humans, Microtubule-Associated Proteins, Mitosis, Models, Genetic, Neoplasms, Phenotype, Protein Structure, Tertiary, Tumor Suppressor Protein p53