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We reported recently that intracerebral administration of NMO-IgG with human complement produces neuromyelitis optica (NMO) lesions in mice. We examined the role of T cells in the formation of NMO lesions by comparing brain histopathology in wildtype and nude mice. Brains were co-injected with IgG from NMO patients and human complement. At 24h and 5days, wildtype vs. nude mouse brains had comparable inflammation (CD45 immunoreactivity), loss of myelin (Luxol Fast Blue staining) and loss of AQP4 immunoreactivity. We conclude that T cells are not required for the formation of NMO lesions in this mouse model.

Original publication

DOI

10.1016/j.jneuroim.2011.03.007

Type

Journal article

Journal

J Neuroimmunol

Publication Date

06/2011

Volume

235

Pages

27 - 32

Keywords

Animals, Brain, Complement System Proteins, Humans, Immunoglobulin G, Immunologic Deficiency Syndromes, Injections, Intraventricular, Mice, Mice, Knockout, Mice, Nude, Neuromyelitis Optica, T-Lymphocytes