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We demonstrate that trypanosomes compromised in flagellar function are rapidly cleared from infected mice. Analysis of the PFR2 bloodstream RNA interference mutant revealed that defective cell motility occurred prior to cytokinesis failure. This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen.

Original publication

DOI

10.1128/EC.00110-07

Type

Journal article

Journal

Eukaryot Cell

Publication Date

07/2007

Volume

6

Pages

1248 - 1250

Keywords

Animals, Cell Movement, Flagella, Humans, Mice, RNA Interference, RNA, Small Interfering, Trypanosoma brucei brucei, Trypanosomiasis, African