Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: Optical mapping is a widely used experimental tool providing high-resolution recordings of cardiac electrical activity. However, the technique is limited by signal distortion due to photon scattering in the tissue. Computational models of the fluorescence recording are capable of assessing these distortion effects, providing important insight to assist experimental data interpretation. METHODS: We present results from a new panoramic optical mapping model, which is used to assess distortion in ventricular optical mapping signals during pacing and arrhythmogenesis arising from 3-dimensional photon scattering. RESULTS/CONCLUSIONS: We demonstrate that accurate consideration of wavefront propagation within the complex ventricular structure, along with accurate representation of photon scattering in 3 dimensions, is essential to faithfully assess distortion effects arising during optical mapping. In this article, examined effects include (1) the specific morphology of the optical action potential upstroke during pacing and (2) the shift in the location of epicardial phase singularities obtained from fluorescent maps.

Original publication

DOI

10.1016/j.jelectrocard.2007.06.020

Type

Conference paper

Publication Date

11/2007

Volume

40

Pages

S75 - S80

Keywords

Animals, Arrhythmias, Cardiac, Body Surface Potential Mapping, Computer Simulation, Heart Conduction System, Humans, Image Interpretation, Computer-Assisted, Microscopy, Fluorescence, Models, Cardiovascular, Photons, Scattering, Radiation