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Non-lytic antibodies to CD4 and certain other T cell adhesion receptors can guide the immune system to become tolerant to foreign antigens, and to regain tolerance in autoimmunity. Tolerance is maintained lifelong through the action of regulatory T cells that in turn can influence naive T cells to acquire the same regulatory properties. A fuller understanding of the molecular basis of infectious tolerance could lead to the design of better immunosuppressive protocols.

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

10/1993

Volume

5

Pages

753 - 758

Keywords

Animals, Antibodies, Monoclonal, Antigen-Presenting Cells, Autoimmunity, Immune Tolerance, T-Lymphocytes, Transplantation Immunology