Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Genetic modification of mosquitoes offers exciting possibilities for controlling malaria, but success will depend on how transformation affects the fitness of modified insects. The expression of an exogenous gene, the mutations caused by its insertion, and inbreeding while transformed lines are established can all lead to reductions in fitness. Factors influencing fitness were investigated in cage experiments with four lines of transgenic Anopheles stephensi, a vector species of human malaria. The results indicate direct costs of the introduced transgene in at least three out of the four lines, as well as an apparent cost of the inbreeding involved in making transgenic homozygotes.

Original publication

DOI

10.1126/science.1081453

Type

Journal article

Journal

Science

Publication Date

21/02/2003

Volume

299

Pages

1225 - 1227

Keywords

Animals, Animals, Genetically Modified, Anopheles, Crosses, Genetic, DNA Transposable Elements, Female, Gene Frequency, Genes, Insect, Genes, Recessive, Genetic Drift, Genetics, Population, Green Fluorescent Proteins, Heterozygote, Homozygote, Inbreeding, Luminescent Proteins, Male, Models, Genetic, Mutation, Oviposition, Transformation, Genetic, Transgenes