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In mouse and chick embryos, cyclic expression of lunatic fringe has an important role in the regulation of mesoderm segmentation. We have isolated a Fringe gene from the protochordate amphioxus. Amphioxus is the closest living relative of the vertebrates, and has mesoderm that is definitively segmented in a manner that is similar to, and probably homologous with, that of vertebrates. AmphiFringe is placed basal to vertebrate Fringe genes in molecular phylogenetic analyses, indicating that the duplications that formed radical-, manic- and lunatic fringe are specific to the vertebrate lineage. AmphiFringe expression was detected in the anterior neural plate of early neurulae, where it resolved into a series of segmental patches by the mid-neurulae stage. No AmphiFringe transcripts were detected in the mesoderm. Based on these observations, we propose a model depicting a successive recruitment of Fringe in the maintenance then regulation of segmentation during vertebrate evolution.

Original publication

DOI

10.1007/s00427-003-0351-7

Type

Journal article

Journal

Dev Genes Evol

Publication Date

10/2003

Volume

213

Pages

505 - 509

Keywords

Amino Acid Sequence, Animals, Base Sequence, Body Patterning, Chordata, Nonvertebrate, DNA Primers, Drosophila Proteins, Evolution, Molecular, Gene Expression, In Situ Hybridization, Likelihood Functions, Mesoderm, Models, Genetic, Molecular Sequence Data, N-Acetylglucosaminyltransferases, Phylogeny, Sequence Alignment, Sequence Analysis, DNA