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Proteins involved in DNA replication are conserved from yeast to mammals, suggesting that the mechanism was established at an early stage of eukaryotic evolution. In spite of this common origin, recent findings have revealed surprising variations in how replication initiation is controlled, implying that a conserved mechanism has not necessarily resulted in regulatory conservation.


Journal article


Mol Cell

Publication Date





1067 - 1075


Animals, Cell Cycle, Cell Cycle Proteins, DNA, DNA Helicases, DNA Replication, DNA, Fungal, DNA-Binding Proteins, Eukaryotic Cells, Origin Recognition Complex