Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Proteins involved in DNA replication are conserved from yeast to mammals, suggesting that the mechanism was established at an early stage of eukaryotic evolution. In spite of this common origin, recent findings have revealed surprising variations in how replication initiation is controlled, implying that a conserved mechanism has not necessarily resulted in regulatory conservation.

Type

Journal article

Journal

Mol Cell

Publication Date

11/2003

Volume

12

Pages

1067 - 1075

Keywords

Animals, Cell Cycle, Cell Cycle Proteins, DNA, DNA Helicases, DNA Replication, DNA, Fungal, DNA-Binding Proteins, Eukaryotic Cells, Origin Recognition Complex