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BACKGROUND: In North America and Europe, human immunodeficiency virus (HIV)-1 infection has typically been dominated by subtype B transmission. More recently, however, non-B subtypes have been increasingly reported in Europe. METHODS: We analyzed 1158 HIV-1-infected individuals in Greece by DNA sequencing and phylogenetic analyses of protease and partial reverse-transcriptase regions. RESULTS: We found that the prevalence of non-B subtypes has increased over time and that this significant trend can be mainly attributed to subtype A, which eventually surpassed subtype B in prevalence in 2004 (42% and 33%, respectively). Multivariate analysis revealed that the year of HIV diagnosis was independently associated with subtype A infection (odds ratio for being infected with subtype A for a 10-year increase in the time period of diagnosis, 2.09 [95% confidence interval, 1.36-3.24]; P

Original publication

DOI

10.1086/521677

Type

Journal article

Journal

J Infect Dis

Publication Date

15/10/2007

Volume

196

Pages

1167 - 1176

Keywords

Adult, Female, Genetic Variation, Greece, HIV Infections, HIV Protease, HIV Reverse Transcriptase, HIV-1, Humans, Male, Middle Aged, Phylogeny, Prevalence