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The beta-lactamases from 403 Moraxella (Branhamella) catarrhalis clinical isolates obtained during 1994-1995 and 1997-1998 U.S. multicenter surveillance studies were characterized by isoelectric focusing. The overall prevalences of the BRO-1 and BRO-2 enzymes among beta-lactamase-positive isolates were estimated to be 97.5 and 2.5%, respectively. The minimum inhibitory concentrations (MICs) of ampicillin for all BRO-2-producing isolates were </=1 microg/ml; however, numerous beta-lactamase-positive isolates for which the ampicillin MICs were </=1 microg/ml produced the BRO-1 enzyme (88. 1%).

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

02/2000

Volume

44

Pages

444 - 446

Keywords

Humans, Isoelectric Focusing, Microbial Sensitivity Tests, Moraxella (Branhamella) catarrhalis, Multicenter Studies as Topic, beta-Lactamases