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Despite efforts from a range of disciplines, our ability to predict and combat the evolution of antibiotic resistance in pathogenic bacteria is limited. This is because resistance evolution involves a complex interplay between the specific drug, bacterial genetics and both natural and treatment ecology. Incorporating details of the molecular mechanisms of drug resistance and ecology into evolutionary models has proved useful in predicting the dynamics of resistance evolution. However, putting these models to practical use will require extensive collaboration between mathematicians, molecular biologists, evolutionary ecologists and clinicians.

Original publication

DOI

10.1038/nrg2778

Type

Journal article

Journal

Nat Rev Genet

Publication Date

06/2010

Volume

11

Pages

405 - 414

Keywords

Animals, Anti-Bacterial Agents, Bacterial Infections, Drug Resistance, Bacterial, Evolution, Molecular, Genetics, Population, Humans, Models, Biological, Signal Transduction, Systems Integration