Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The transcription factor Krox-20 has roles in the maintenance of segmentation and specification of segment identity in the vertebrate hindbrain. Overt hindbrain segmentation is a vertebrate novelty, and is not seen in invertebrate chordates such as amphioxus and tunicates. To test if the roles of Krox-20 are also derived, we cloned a Krox-20 related gene, AmphiKrox, from amphioxus. AmphiKrox is related to a small family of vertebrate Krox genes and is expressed in the most anterior region of the amphioxus brain and in the club shaped gland, a secretory organ that develops in the anterior pharynx. Neither expression domain overlaps with the expression of AmphiHox-1, -2, -3 or -4, suggesting that the roles of Krox-20 in hindbrain segmentation and in Hox gene regulation were acquired concomitant with the duplication of Krox genes in vertebrate evolution.

Original publication

DOI

10.1007/s004270050341

Type

Journal article

Journal

Dev Genes Evol

Publication Date

10/2000

Volume

210

Pages

518 - 521

Keywords

Amino Acid Sequence, Animals, Chordata, Nonvertebrate, DNA, Complementary, DNA-Binding Proteins, Early Growth Response Protein 2, Humans, Molecular Sequence Data, Rhombencephalon, Sequence Homology, Amino Acid, Transcription Factors