Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The C2H2 zinc finger is one of the most common domains encoded by animal genomes and has been implicated in DNA binding as well as protein-protein interactions and RNA binding. Genes encoding C2H2 zinc finger domains include not only well-studied conserved transcription factors such as Gli and Snail but also include a large diversity of more rapidly evolving genes. Here, I focus on the description of amphioxus members of families and super-families of C2H2 zinc finger genes that have been the subject of functional studies in other species, specifically the Gli, Zic, Glis, Snail, Scratch, Krox, Wilms' tumour, Huckebein, SP, KLF, Ovo, Spalt, Blimp-1, Odd and Fez genes. Surveys of the Branchiostoma floridae genome reveal members of all of these groups of genes. Genes are named according to molecular phylogenetic analyses, such that the nomenclature reflects pre-existing gene names in the context of gene families that have descended from a single common ancestral gene in the common ancestor of chordates and insects. In total, this comprises 28 B. floridae C2H2 zinc finger genes, representing at least 15 gene families. For 17 of these genes, expressed sequence tag clusters and associated clone identification codes relating to the B. floridae gene collection are given.

Original publication

DOI

10.1007/s00427-008-0248-6

Type

Journal article

Journal

Dev Genes Evol

Publication Date

12/2008

Volume

218

Pages

639 - 649

Keywords

Animals, Chordata, Nonvertebrate, Genome, Phylogeny, Transcription Factors, Zinc Fingers