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Invasive disease caused by the encapsulated bacteria Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae remains an important cause of morbidity and mortality worldwide, despite the introduction of successful conjugate polysaccharide vaccines that target disease-associated strains. In addition, resistance, or more accurately reduced susceptibility, to therapeutic antibiotics is spreading in populations of these organisms. There is therefore a continuing requirement for the surveillance of vaccine and non-vaccine antigens and antibiotic susceptibilities among isolates from invasive disease, which is only partially met by conventional methods. This need can be met with molecular and especially nucleotide sequence-based typing methods, which are fully developed in the case of N. meningitidis and which could be more widely deployed in clinical laboratories for S. pneumoniae and H. influenzae.

Original publication

DOI

10.1099/mic.0.050518-0

Type

Journal article

Journal

Microbiology

Publication Date

08/2011

Volume

157

Pages

2181 - 2195

Keywords

Disease Outbreaks, Haemophilus Infections, Haemophilus influenzae, Humans, Meningococcal Infections, Microbial Sensitivity Tests, Molecular Epidemiology, Molecular Typing, Neisseria meningitidis, Pneumococcal Infections, Population Surveillance, Streptococcus pneumoniae