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The nuclear envelope is not only important for the structural integrity of the nucleus, but also involved in a number of cellular functions. It has been shown to be important for maintaining and controlling chromatin organization, sequestering transcription factors, replication, transcription and signalling. The nuclear envelope is thus important for development and differentiation, and some of its components are essential for cell viability. Among the many functions which are emerging for the nuclear envelope is its involvement in protecting the cell against different types of cellular stress. In the present paper, we review key findings which describe the roles of nuclear envelope components in responses to common types of stress conditions.

Original publication




Journal article


Biochem Soc Trans

Publication Date





1795 - 1798


Animals, DNA Damage, Heat-Shock Response, Humans, Nuclear Envelope, Osmotic Pressure, Oxidative Stress, Stress, Physiological