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The rate at which X-ray structures of membrane proteins are solved is on a par with that of soluble proteins in the late 1970s. There are still many obstacles facing the membrane protein structural community. Recently, there have been several technical achievements in the field that have started to dramatically accelerate structural studies. Here, we summarize these so-called 'tricks-of-the-trade' and include case studies of several mammalian transporters.

Original publication

DOI

10.1016/j.febslet.2010.04.015

Type

Journal article

Journal

FEBS Lett

Publication Date

18/06/2010

Volume

584

Pages

2539 - 2547

Keywords

Animals, Crystallization, Detergents, Glucose Transporter Type 1, Green Fluorescent Proteins, Humans, Membrane Proteins, Protein Stability, Rats, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Vesicular Glutamate Transport Protein 2