Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T cells from tolerant mice disabled naïve lymphocytes so that they too could not reject the graft. The naïve lymphocytes that had been so disabled also became tolerant and, in turn, developed the capacity to specifically disable other naïve lymphocytes. This process of "infectious" tolerance explains why no further immunosuppression was needed to maintain long-term transplantation tolerance.


Journal article



Publication Date





974 - 977


Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, CD2 Antigens, CD4 Antigens, CD4-Positive T-Lymphocytes, CD8 Antigens, Graft Rejection, Immune Tolerance, Mice, Mice, Inbred BALB C, Mice, Inbred CBA, Mice, Transgenic, Receptors, Immunologic, Skin Transplantation, Spleen