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The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T cells from tolerant mice disabled naïve lymphocytes so that they too could not reject the graft. The naïve lymphocytes that had been so disabled also became tolerant and, in turn, developed the capacity to specifically disable other naïve lymphocytes. This process of "infectious" tolerance explains why no further immunosuppression was needed to maintain long-term transplantation tolerance.

Type

Journal article

Journal

Science

Publication Date

12/02/1993

Volume

259

Pages

974 - 977

Keywords

Animals, Antibodies, Monoclonal, Antigens, CD2, Antigens, CD4, Antigens, CD8, Antigens, Differentiation, T-Lymphocyte, CD4-Positive T-Lymphocytes, Graft Rejection, Immune Tolerance, Mice, Mice, Inbred BALB C, Mice, Inbred CBA, Mice, Transgenic, Receptors, Immunologic, Skin Transplantation, Spleen