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We have shown that the benzimidazole carbamate, parbendazole, is a potent inhibitor of microtubule assembly in vitro and in vivo. Radiolabelled parbendazole was shown to bind to purified tubulin. Immunofluorescence studies using antitubulin antibody showed that parbendazole effectively depolymerizes cytoplasmic microtubules in animal cells leaving only one or two microtubules associated with one centriole. The usefulness of parbendazole and other benzimidazole carbamates as inhibitors of microtubule functions is discussed.

Type

Journal article

Journal

J Cell Sci

Publication Date

06/1981

Volume

49

Pages

195 - 204

Keywords

Animals, Benzimidazoles, Binding Sites, Cell Line, Cercopithecus aethiops, Depression, Chemical, Fluorescent Antibody Technique, Kinetics, Microtubules, Tubulin