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Nondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag reactive T cells. However, this may not be the sole explanation for tolerance, as we show in this study that tolerance is maintained through a dominant regulatory mechanism which, like tolerance induced with CD4 Abs, manifests as infectious tolerance. Therefore, tolerance induced with anti-CD154 Abs involves not only the deletion of potentially aggressive T cells, but also a contagious spread of tolerance to new cohorts of graft-reactive T cells as they arise.

Type

Journal article

Journal

J Immunol

Publication Date

01/11/2000

Volume

165

Pages

4783 - 4786

Keywords

Adoptive Transfer, Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antibodies, Neoplasm, CD40 Ligand, CD8-Positive T-Lymphocytes, Injections, Intraperitoneal, Injections, Intravenous, Lymphocyte Depletion, Lymphocyte Transfusion, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Transgenic, Skin Transplantation, T-Lymphocytes, Thymectomy, Transplantation Tolerance