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Solute carriers (SLCs) control the flow of small molecules and ions across biological membranes. Over the last 20 years, the pace of research in SLC biology has accelerated markedly, opening new opportunities to treat metabolic diseases, cancer and neurological disorders. Recently, new families of atypical SLCs, with roles in organelle biology, metabolite signaling and trafficking, have expanded their roles in the cell. This Perspective discusses work leading to current advances and the emerging opportunities to target and modulate SLCs to uncover new biology and treat human disease.

Original publication

DOI

10.1038/s41594-024-01271-0

Type

Journal article

Journal

Nat Struct Mol Biol

Publication Date

04/2024

Volume

31

Pages

587 - 590

Keywords

Humans, Cell Membrane, Biology