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It is now possible to induce donor-specific transplantation tolerance in adult rodents using a number of therapeutic strategies. Such peripheral tolerance is maintained by regulatory CD4+ T cells, not only in transplantation models, but also in autoimmunity. Differential gene expression analyses have been used to identify potential new markers for regulatory T cells, aiming to reveal new insights into their mechanisms of action, and to find novel targets for therapeutic manipulation of the immune system.

Type

Journal article

Journal

Semin Immunol

Publication Date

08/2003

Volume

15

Pages

209 - 214

Keywords

Animals, Biomarkers, Gene Expression Profiling, Gene Expression Regulation, Humans, Immune Tolerance, T-Lymphocytes, Th1 Cells