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It is now possible to induce donor-specific transplantation tolerance in adult rodents using a number of therapeutic strategies. Such peripheral tolerance is maintained by regulatory CD4+ T cells, not only in transplantation models, but also in autoimmunity. Differential gene expression analyses have been used to identify potential new markers for regulatory T cells, aiming to reveal new insights into their mechanisms of action, and to find novel targets for therapeutic manipulation of the immune system.


Journal article


Semin Immunol

Publication Date





209 - 214


Animals, Biomarkers, Gene Expression Profiling, Gene Expression Regulation, Humans, Immune Tolerance, T-Lymphocytes, Th1 Cells