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Bacterial multidrug resistance is a serious clinical problem and is commonly conferred by tripartite efflux 'pumps' in the prokaryotic cell envelope. Crystal structures of the three components of a drug efflux pump have now been solved: the outer membrane TolC exit duct in the year 2000, the inner membrane AcrB antiporter in 2002 and the periplasmic adaptor MexA in 2004. These structures have enhanced our understanding of the principles underlying pump assembly and operation, and present pumps as new drug targets.

Original publication

DOI

10.1016/j.sbi.2004.10.003

Type

Journal article

Journal

Curr Opin Struct Biol

Publication Date

12/2004

Volume

14

Pages

741 - 747

Keywords

Animals, Anti-Bacterial Agents, Bacterial Outer Membrane Proteins, Bacterial Proteins, Biological Transport, Active, Carrier Proteins, Cell Membrane, Escherichia coli Proteins, Humans, Membrane Proteins, Membrane Transport Proteins, Models, Biological, Models, Chemical, Models, Molecular, Multidrug Resistance-Associated Proteins, Protein Conformation, Structure-Activity Relationship