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The PfEMP1 proteins of the malaria parasite Plasmodium falciparum are inserted into the membrane of infected red blood cells, where they mediate adhesion to a variety of human receptors. The DBL domains of the var2csa-encoded PfEMP1 protein play a critical role in malaria of pregnancy, tethering infected cells to the surface of the placenta through interactions with the glycosaminoglycan carbohydrate chondroitin sulfate A (CSA). A CSA-binding DBL domain has been overproduced in a bacterial expression system, purified and crystallized. Native data sets extending to 1.9 A resolution have been collected and phasing is under way.

Original publication

DOI

10.1107/S1744309108004211

Type

Journal article

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun

Publication Date

01/03/2008

Volume

64

Pages

221 - 223

Keywords

Animals, Antigens, Protozoan, Chondroitin Sulfates, Crystallization, Plasmodium falciparum, Protein Binding, Protozoan Proteins, X-Ray Diffraction