Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Highly active antiretroviral therapy (HAART) has resulted in a reduction of morbidity and mortality in HIV-associated cerebral opportunistic infection. Before HAART, up to 50% of all HIV-infected patients in Europe developed cerebral toxoplasmosis, an encephalitis caused by reactivation of Toxoplasma gondii infection. Although potent therapeutical options exist, the prognosis is still poor. We describe the course of 36 AIDS patients with cerebral toxoplasmosis and present a review of clinical signs, diagnosis, therapy, and survival times. The main criteria for differential diagnosis from other secondary neuromanifestations such as primary CNS lymphoma, progressive multifocal leukencephalopathy, abscesses, and ischemic infarctions are described. Indications and problems of stereotactic biopsy are discussed.

Original publication

DOI

10.1007/s00115-002-1416-y

Type

Journal article

Journal

Nervenarzt

Publication Date

12/2002

Volume

73

Pages

1174 - 1178

Keywords

AIDS-Related Opportunistic Infections, Acquired Immunodeficiency Syndrome, Adult, Aged, Antiretroviral Therapy, Highly Active, Brain, Dapsone, Diagnosis, Differential, Diagnostic Imaging, Drug Combinations, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pyrimethamine, Retrospective Studies, Sulfadoxine, Survival Rate, Toxoplasmosis, Cerebral, Trimethoprim, Sulfamethoxazole Drug Combination