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Dynamic interactions between membrane and cytoskeleton components are crucial for T cell antigen recognition and subsequent cellular activation. We report here that the membrane-microfilament linker ezrin plays an important role in these processes. First, ezrin relocalizes to the contact area between T cells and stimulatory antigen-presenting cells (APCs), accumulating in F-actin-rich membrane protrusions at the periphery of the immunological synapse. Second, T cell receptor (TCR)-mediated intracellular signals are sufficient to induce ezrin relocalization, indicating that this protein is an effector of TCR signaling. Third, overexpression of the membrane binding domain of ezrin perturbs T cell receptor clustering in the T cell-APC contact area and inhibits the activation of nuclear factor for activated T cells (NF-AT).

Type

Journal article

Journal

Immunity

Publication Date

11/2001

Volume

15

Pages

715 - 728

Keywords

Cell Communication, Cytoskeletal Proteins, Humans, Immunity, Cellular, Jurkat Cells, Lymphocyte Activation, Phosphoproteins, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes