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We studied the effect of the tricyclic antidepressant lofepramine (140-210 mg daily for 16 days) on 5-hydroxytryptamine 1A (5-HT1A) receptor sensitivity in healthy volunteers, using a buspirone neuroendocrine challenge paradigm (30 mg orally). We also studied the effect of lofepramine on platelet 5-HT content and sleep architecture. Lofepramine treatment did not alter the hypothermic, endocrine or amnesic effects of buspirone but significantly lowered platelet 5-HT content and decreased rapid eye movement sleep. Our findings suggest that at clinically used doses, lofepramine inhibits the uptake of 5-HT and produces changes in sleep architecture characteristic of tricyclic antidepressants. However, lofepramine does not appear to alter the sensitivity of 5-HT1A receptors.

Type

Journal article

Journal

J Affect Disord

Publication Date

09/1993

Volume

29

Pages

63 - 72

Keywords

Adult, Blood Platelets, Buspirone, Electroencephalography, Humans, Lofepramine, Male, Memory, Prolactin, Receptors, Serotonin, Serotonin, Sleep, Sleep, REM