Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Administration of bicuculline (3.5 mg/kg i.p.) or pentylenetetrazol (30 mg/kg i.p.) 3 min before each of a series of 5 electroconvulsive shocks (ECS), given over 10 days (1, 3, 5, 8 and 10), prevented the enhanced behavioural responses to the dopamine agonist apomorphine and the 5-hydroxytryptamine agonist quipazine 24 hr after the last application of ECS. Pretreatment with these antagonists of gamma-aminobutyric acid (GABA) also abolished the rise in the concentration of GABA in the corpus striatum, normally seen after repeated ECS. Taken with data showing that the change in GABA concentration occurred at times when enhanced monoamine-mediated behavioural responses were seen, these results suggest that the enhanced behavioural responses following repeated ECS might be associated with changes in GABA function. Daily injection for 8 days with pentylenetetrazol (30 mg/kg) resulted in enhanced apomorphine-mediated behaviour. However, there was no change in the concentration of striatal GABA at this time.

Type

Journal article

Journal

Neuropharmacology

Publication Date

10/1982

Volume

21

Pages

981 - 984

Keywords

Animals, Apomorphine, Behavior, Animal, Brain Chemistry, Electroshock, GABA Antagonists, Male, Pentylenetetrazole, Quipazine, Rats, Rats, Inbred Strains, gamma-Aminobutyric Acid