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The effects of the benzodiazepine antagonist, Ro 15-1788 on ethanol withdrawal convulsions were investigated in rats. The study originated from recent reports of benzodiazepine binding activity in urine of alcoholics during withdrawal. No alleviation of convulsions was found with Ro 15-1788. This suggested that this component of the withdrawal syndrome is not due to endogenous production of a benzodiazepine inverse agonist (contragonist), as Ro 15-1788 prevents the action of this type of compound.

Type

Journal article

Journal

Eur J Pharmacol

Publication Date

08/01/1985

Volume

107

Pages

375 - 377

Keywords

Animals, Benzodiazepines, Benzodiazepinones, Ethanol, Flumazenil, Humans, Male, Rats, Rats, Inbred Strains, Seizures, Substance Withdrawal Syndrome