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The effects of the 5-hydroxytryptamine (5-HT) uptake inhibitor clomipramine on the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) were assessed in six normal subjects. Oral administration of 20 mg clomipramine 2 h prior to LTP infusion (50 mg/kg) significantly enhanced both endocrine responses, suggesting that the increases in plasma PRL and GH produced by LTP are mediated by 5-HT pathways. These findings, taken together with previous observations that 5-HT2 receptor antagonists do not attenuate the PRL response to LTP, suggest that the 5-HT-induced release of PRL in man may be mediated by 5-HT1 receptors.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1986

Volume

89

Pages

131 - 133

Keywords

Adult, Brain, Clomipramine, Drug Synergism, Growth Hormone, Humans, Injections, Intravenous, Male, Neural Pathways, Prolactin, Serotonin, Synaptic Transmission, Tryptophan