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The effects of acute and chronic diazepam administration on L-tryptophan induced prolactin release was studied in seven male volunteers. Acute diazepam diminished the prolactin neuroendocrine response to L-tryptophan. On chronic administration this effect was lost, suggesting tolerance had developed. The sedative effects of L-tryptophan were unaltered by either acute or chronic diazepam administration. A possible explanation for the tolerance development to the neuroendocrine effects may be the observed reduction in platelet 3H-imipramine binding that was observed.


Journal article


Pharmacol Biochem Behav

Publication Date





1491 - 1495


Adult, Blood Platelets, Diazepam, Humans, Hypnotics and Sedatives, Imipramine, Male, Nordazepam, Prolactin, Serotonin, Time Factors, Tryptophan