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Based upon animal experiments and early clinical trials, neurokinin-1 receptor antagonists showed promise as novel antidepressants. Subsequently, however, more extensive clinical trials did not reveal evidence of efficacy in depression. The development of novel antidepressants will require a better understanding of the neural basis of antidepressant action in humans.

Original publication

DOI

10.1192/bjp.bp.107.037879

Type

Journal article

Journal

Br J Psychiatry

Publication Date

10/2007

Volume

191

Pages

282 - 284

Keywords

Animals, Antidepressive Agents, Clinical Trials as Topic, Depressive Disorder, Drug Design, Humans, Models, Animal, Morpholines, Neurokinin-1 Receptor Antagonists, Substance P