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Healthy volunteers who received i.v. injections of either saline or haloperidol (0.5 or 1.0 mg) made visual analogue scale ratings of subjective mood, tension, shakiness and the global feeling of having received an active drug. The subjective ratings of volunteers who received haloperidol did not differ, overall, from those who received saline. In contrast, the drug caused clear objective changes in several psychological tests. I.v. administration of low doses of haloperidol may permit double-blind testing of the psychological actions of haloperidol in healthy volunteers.

Original publication

DOI

10.1177/026988119701100308

Type

Journal article

Journal

J Psychopharmacol

Publication Date

1997

Volume

11

Pages

247 - 252

Keywords

Affect, Antipsychotic Agents, Attention, Blood Pressure, Double-Blind Method, Female, Haloperidol, Heart Rate, Humans, Injections, Intravenous, Male