Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The recent determination of the structure of a complex formed between the HIV-1 glycoprotein gp120, CD4 and an antibody fragment has revealed new mechanisms for viral evasion of the immune response and shed light on how the virus enters target cells. The results of this work, together with related biochemical studies, may assist in the future design of therapeutic strategies against HIV-1 infection.

Type

Journal article

Journal

Structure

Publication Date

15/08/1998

Volume

6

Pages

945 - 949

Keywords

Antigens, CD4, HIV Envelope Protein gp120, HIV-1, Immunoglobulin Fab Fragments, Models, Molecular, Protein Conformation, Protein Structure, Secondary, Receptors, HIV