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The recent determination of the structure of a complex formed between the HIV-1 glycoprotein gp120, CD4 and an antibody fragment has revealed new mechanisms for viral evasion of the immune response and shed light on how the virus enters target cells. The results of this work, together with related biochemical studies, may assist in the future design of therapeutic strategies against HIV-1 infection.


Journal article



Publication Date





945 - 949


CD4 Antigens, HIV Envelope Protein gp120, HIV-1, Immunoglobulin Fab Fragments, Models, Molecular, Protein Conformation, Protein Structure, Secondary, Receptors, HIV