Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Campath 6, a rat IgG2b monoclonal antibody to the interleukin 2 receptor on activated T cells, was used to treat three patients with active rheumatoid arthritis unresponsive to conventional treatment. Two patients had an excellent response for about three months. There were no significant side effects. The results suggest that activated T cells are of importance in the pathogenesis of rheumatoid arthritis. Although infusions of rat monoclonal antibodies could not be repeated because of the risk of sensitisation, the development of humanised monoclonal antibodies targeted against specific T cell sets would allow repeated courses of treatment to be given.

Type

Journal article

Journal

Ann Rheum Dis

Publication Date

05/1989

Volume

48

Pages

428 - 429

Keywords

Adult, Antibodies, Monoclonal, Arthritis, Rheumatoid, Female, Humans, Lymphocyte Activation, Male, Middle Aged, Receptors, Interleukin-2, T-Lymphocytes