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Lombardi et al. (Reports, 23 October 2009, p. 585) reported a significant association between the human retrovirus XMRV and chronic fatigue syndrome (CFS). However, the cases with CFS and the control subjects in their study are poorly described and unlikely to be representative. Independent replication is a critical first step before accepting the validity of this finding.

Original publication

DOI

10.1126/science.1183706

Type

Journal article

Journal

Science

Publication Date

14/05/2010

Volume

328

Keywords

Blood Cells, Case-Control Studies, Epidemiologic Research Design, Fatigue Syndrome, Chronic, Gammaretrovirus, Humans, Reproducibility of Results, Retroviridae Infections, Tumor Virus Infections