Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The humoral immune response to HIV-1 has been extensively studied over the past few years and considerable advances have been made in understanding the dynamics and specificity of the neutralizing antibody component during and after seroconversion. Despite this, there is still no clear understanding of the role of neutralizing antibodies in controlling or preventing HIV-1 infection. Candidate vaccines have been based on immunogens designed to elicit a neutralizing response, but the recent vaccine trial failures force us to reconsider the role of neutralizing antibodies in HIV-1 infection and the type of vaccine preparation used.


Journal article


Curr Opin Immunol

Publication Date





540 - 545


AIDS Vaccines, Binding, Competitive, HIV Antibodies, HIV-1, Humans, Neutralization Tests