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HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.

Type

Journal article

Journal

Trends Microbiol

Publication Date

04/1999

Volume

7

Pages

144 - 149

Keywords

Antigens, CD4, Cell Adhesion Molecules, HIV Envelope Protein gp120, HIV Infections, HIV-1, Heparan Sulfate Proteoglycans, Humans, Receptors, CCR5, Receptors, CXCR4, Receptors, Cell Surface