Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.


Journal article


Trends Microbiol

Publication Date





144 - 149


CD4 Antigens, Cell Adhesion Molecules, HIV Envelope Protein gp120, HIV Infections, HIV-1, Heparan Sulfate Proteoglycans, Humans, Receptors, CCR5, Receptors, CXCR4, Receptors, Cell Surface