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A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.

Type

Journal article

Journal

Science

Publication Date

19/10/1984

Volume

226

Pages

348 - 349

Keywords

Animals, Chromosome Mapping, Chromosomes, Human, 6-12 and X, Cloning, Molecular, DNA, Genes, Genetic Linkage, Humans, Hybrid Cells, Immunoglobulin kappa-Chains, Major Histocompatibility Complex, Mice, Nucleic Acid Hybridization, Receptors, Antigen, T-Cell