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Although Alzheimer's disease, Parkinson's disease, and motor neurone disease are distinct disorders, there could be a common neurodegenerative mechanism that characterises the death of selective neurone populations in each case. We propose that this mechanism could be an aberrantly activated, developmental process involving a non-classical, non-enzymatic action of acetylcholinesterase mediated via a short linear motif near the C-terminal end of the molecule. Since this motif has a highly conserved homology with part of the amyloid precursor protein, it may be particularly attractive as a target for novel therapeutic strategies in neurodegeneration.

Type

Journal article

Journal

Neuroscience

Publication Date

2002

Volume

113

Pages

485 - 492

Keywords

Acetylcholinesterase, Alzheimer Disease, Amino Acid Sequence, Amyloid beta-Protein Precursor, Animals, Cell Death, Humans, Molecular Sequence Data, Motor Neuron Disease, Parkinson Disease