Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We report the genomic organization of the human CD2 gene and its expression in transgenic mice. A 28.5 kb segment of DNA consisting of 4.5 kb 5' flanking sequences, 15 kb containing the gene's five exons and 9 kb of 3' flanking sequences can direct the expression of the CD2 gene only on thymocytes, circulating T cells and megakaryocytes of the transgenic mice. The expression of each copy of the human CD2 transgene appears to be as high as the endogenous mouse CD2 gene and as high as the expression on the surface of human T lymphocytes, independent of the site of integration and dependent on the copy number of genes that have integrated.

Type

Journal article

Journal

EMBO J

Publication Date

06/1988

Volume

7

Pages

1675 - 1682

Keywords

Amino Acid Sequence, Animals, Antigens, CD2, Antigens, Differentiation, T-Lymphocyte, Base Sequence, Bone Marrow, Gene Expression Regulation, Genes, Humans, Lymphoid Tissue, Mice, Mice, Transgenic, Molecular Sequence Data, RNA, Messenger, Receptors, Immunologic, Recombinant Proteins, Spleen