A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Sri S., Greenstein A., Granata A., Collcutt A., Jochems ACC., McColl BW., Castro BD., Webber C., Reyes CA., Hall C., Lawrence CB., Hawkes C., Pegasiou-Davies C-M., Gibson C., Crawford CL., Smith C., Vivien D., McLean FH., Wiseman F., Brezzo G., Lalli G., Pritchard HAT., Markus HS., Bravo-Ferrer I., Taylor J., Leiper J., Berwick J., Gan J., Gallacher J., Moss J., Goense J., McMullan L., Work L., Evans L., Stringer MS., Ashford M., Abulfadl M., Conlon N., Malhotra P., Bath P., Canter R., Brown R., Ince S., Anderle S., Young S., Quick S., Szymkowiak S., Hill S., Allan S., Wang T., Quinn T., Procter T., Farr TD., Zhao X., Yang Z., Hainsworth AH., Wardlaw JM.
Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.