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The immune system is organized so as to react to pathogens without risking damage to self. Harnessing those processes that prevent self-reactivity will have enormous potential in clinical medicine. This review outlines the efforts of this laboratory over the last 25 years to exploit tolerance so as to reprogram the immune system for therapeutic purposes.

Type

Journal article

Journal

Immunol Rev

Publication Date

07/2002

Volume

185

Pages

227 - 235

Keywords

Allergy and Immunology, Animals, Graft Rejection, Graft Survival, History, 20th Century, Humans, Immune System, Immune Tolerance, Models, Immunological